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Novartis anti-cancer drug camatinib has been approved in China for new indications for METex14 jump mutation NSCLC

2025-09-19 04:29:15 healthy

Novartis anti-cancer drug camatinib has been approved in China for new indications for METex14 jump mutation NSCLC

Recently, Novartis announced that its anti-cancer drug Capmatinib has been approved in China for the treatment of patients with non-small cell lung cancer (NSCLC) with a jump mutation in METex14. This approval provides a new targeted treatment option for lung cancer patients in China, marking another important progress in precision medicine in the field of lung cancer.

The clinical value of camatinib

Novartis anti-cancer drug camatinib has been approved in China for new indications for METex14 jump mutation NSCLC

Camatinib is a highly selective MET inhibitor that blocks the growth and spread of tumor cells by inhibiting the MET signaling pathway. The METex14 jump mutation is a rare driver gene mutation in NSCLC, accounting for about 3%-4% of all NSCLC cases. Previously, the lack of effective targeted therapeutic drugs in this type of patient, and the approval of camatinib fills this gap.

Clinical trial data

The approval of camatinib is based on data from a number of clinical trials, among which the results of the key study GEOMETRY mono-1 show that camatinib shows significant anti-tumor activity in patients with METex14 jump mutation NSCLC. Here are the main data from the study:

indexFirst treatment patients (n=28)Treated patients (n=69)
Objective Remission Rate (ORR)67.9%40.6%
Median duration of remission (DOR)12.6 months9.7 months
Median progression-free survival (PFS)9.1 month5.4 months

The significance of the approval of indications

The approval of camatinib not only provides a new treatment option for patients with METex14 jump mutation NSCLC, but also further promotes the development of precise treatment of lung cancer. The following are the challenges faced by lung cancer patients in China and the significance of camatinib:

challengeThe significance of camatinib
Patients with METex14 jump mutation lack targeted drugsFill in the treatment gap and provide efficient targeted solutions
Traditional chemotherapy has limited effectSignificantly improve objective remission rate and survival period
Low popularity of genetic testingPromote the clinical application of MET gene detection

Domestic and foreign experts' opinions

Experts at home and abroad highly praised the approval of camatinib. Chinese lung cancer experts said that the launch of camatinib will change the treatment pattern of METex14 jump mutation NSCLC and bring more hope for survival to patients. International experts also pointed out that the efficacy data of camatinib is encouraging and is another milestone in precision medicine.

Future Outlook

With camatinib approved in China, Novartis plans to further expand its accessibility and strive to include drugs in the medical insurance catalog through cooperation with the medical insurance department to reduce the financial burden on patients. In addition, research on camatinib in other cancer types is also underway, which may bring good news to more patients in the future.

Conclusion

The approval of camatinib in China is an important advance in the field of targeted treatment of lung cancer, providing new hope for survival for patients with METex14 jump-mutant NSCLC. With the continuous development of precision medicine, more patients will benefit from individualized treatment in the future.

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